Here we present zircon petrochronological data, tephra whole-rock/glass compositions, and amphibole thermobarometry comprising the last four explosive eruptions of Ilopango Caldera in El Salvador (Tierra Blanca eruptive suite, TB). Our datasets include 238U-230Th disequilibrium geochronology, trace-elements, and oxygen isotope compositions from polished and unpolished zircon crystals analyzed using a CAMECA IMS 1280-HR secondary ion mass spectrometer (SIMS) at Heidelberg University, Germany. Additionally, pumice clasts whole-rock chemical analyses from the TB suite were performed at the German Research Centre for Geosciences (GFZ) using a PANalytical AXIOS Advanced wavelength-dispersive spectrometer, whereas major and trace-elements, glass shard, and mineral compositions were collected using an electron microprobe analysis (EMPA) at GEOMAR - Helmholtz-Centre for Ocean Research Kiel and by Laser Ablation Inductively Coupled Plasma - Mass Spectrometry (LA-ICP-MS) at Institute of Earth Sciences, Academia Sinica in Taipei. Whole-rock Sr-Nd isotope determinations were carried out at Departamento de Geología, Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE; Mexico) with a Nu-Instruments thermal ionization mass spectrometer (Nu-TIMS), whereas whole-rock U-series were determined using a ThermoFisher Neptune inductively-coupled mass-spectrometer multi-collector (ICP-MS-MC) at the University of Wyoming (UWYO, USA).