Model runs over Europe were conducted within the ESM project (www.esm-project.net/) for the Frontier Simulations supporting the water and matter fluxes from the European landmass to receiving water bodies (Baltic Sea, Atlantic Ocean and the Mediterranean Sea). Daily discharge from the mesoscale Hydrologic Model (mHM; Samaniego et al., 2010; Kumar et al., 2013; Code version: git.ufz.de/mhm/mhm git version: 35b5cb1) operated at the spatial resolution of 1/16deg for the simulation period from 1.1.1960-31.12.2022 across the European domain (Longitude -11 to 41 Latitude 35 to 72). Model runs were conducted within the ESM project (www.esm-project.net/) for the Frontier Simulations supporting the water and matter fluxes from the European landmass to receiving water bodies (Baltic Sea, Atlantic Ocean and Mediterranian Sea). Special consideration was given to the coastal cells by filtering out those (bordering) grid cells that do not have 100% landmass (i.e., cells with a significant proportion of water bodies/sea/ocean coverage). Meteorological forcing data are based on the E-OBS v21e (daily precipitation, temperature, Hofstra et al. 2009), potential evapotranspiration is based on the Hargreaves-Samani method. Soil characteristics are obtained from the global SoilGrids database (Hengtl et al. 2014; the land cover is derived from the Globcover_V2 (http://due.esrin.esa.int/page_globcover.php); geomorphological features are based on the GMTED2010 (Danielson et al., 2011). Model parameterization was constrained using the observed discharge time series from the GRDC stations (https://portal.grdc.bafg.de/), satisfying the following three conditions: gauge LAT>48degN, area> 5000km2, area <170000km2. Multi-basin calibration and validation were employed to check the consistency of model simulations following Rakovec et al., 2016 and Samaniego et al. 2019, as follows. Calibration objective function using KGE, DDS algorithm with 500 iterations, to account for uncertainty in the calibration process and the basin selections, 50 random initial conditions were randomly drawn sub-set of basins (N=6basins). The best parameter set in the cross-validations across 1201 basins was selected for the final run (ID: 542). A static 2D file of flow direction over Europe at the routing resolution 1/16deg. Internal upscaling to 1/16deg from the higher resolution (1/512deg) done within mHM (Code version: mesoscale Hydrologic Model (git.ufz.de/mhm/mhm git version: 35b5cb1). Special consideration was given to the coastal cells by filtering out those (bordering) grid cells that do not have 100% landmass (i.e., cells with a significant proportion of water bodies/sea/ocean coverage). Flow direction network (lat,lon) and routed runoff (time,lat,lon) at 1/16deg are provided as separate datasets. Meteorological forcing data of the mHM model from 1.1.2020 to 31.12.2022 are based on the E-OBS v26e.