Designing polymer therapeutics to diffuse through mucin

DOI

Progress in the development of nano-sized hybrid therapeutics and nano-sized drug delivery systems - "nanomedicines" - over the last decade has been remarkable. One key requirement is the knowledge of how polymers interact with the many biological barriers that they meet en route to the site of action. Current research is studying dendrimers, dendrons and dendronised polymers as these more branched architectures rapidly traffic through cells showing high levels of exocytosis or transcytosis across biological barrierslike the gastrointestinal tract. The question is why ? The focus of a new PhD project here in Cardiff is to probe the diffusion of polymeric vehicles through, and their impact on, the structure of the mucous layer that exists on many epithelial surfaces, arguably the ultimate barrier to a successful drug delivery.

Identifier
DOI https://doi.org/10.5286/ISIS.E.24003164
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24003164
Provenance
Creator Professor Peter Griffiths; Miss Paola Occhipinti; Dr Mark Gumbleton
Publisher ISIS Neutron and Muon Source
Publication Year 2010
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2007-11-30T09:45:28Z
Temporal Coverage End 2007-12-03T23:56:38Z