Molecular, cytological and hystological basics of annelid reparative regeneration regulation

Annelids are becoming more and more popular model to study regeneration, as, being highly organized animals, they can restore the whole body from a single segment and different annelids possess variable regenerative capacities. Despite a large amount of works on polychaetes regeneration we are far from understanding why some animals can easily growth out both body ends and some can hardly heal the injury. Our project is devoted to the reading, assembly and analysis of trascriptomes of two polychaetes Platynereis dumerilii (Nereididae, Annelida) and Pygospio elegans (Spionidae, Annelida) at different stages of their regeneration. P.dumerilii is only capable of caudal regeneration, while P.elegans can quickly restore both the head and the tail body parts in case of loss. We consider it to be of great interest to compare the gene sets that are activated at different timepoints at the head and tail regeneration sites. We hope that in the case of success our data will help to answer a number of questions, i.e. (i) which genes are activated at the head and tail cut sites at different timepoints of regeneration process of two polychaetes that varies in their regenerative capacities (ii) which conservative regulatory genes are involved in polychaete regeneration (iii) which genes demonstrate the differential expression in the areas of anterior and posterior regeneration (iv) why P. dumerilii lacks the anterior regeneration.

Identifier
Source https://data.blue-cloud.org/search-details?step=~012C2658B46E194E750FE3B6E62A9C5E6FD9DCB9D12
Metadata Access https://data.blue-cloud.org/api/collections/C2658B46E194E750FE3B6E62A9C5E6FD9DCB9D12
Provenance
Instrument Illumina HiSeq 2500; Illumina NovaSeq 6000; ILLUMINA
Publisher Blue-Cloud Data Discovery & Access service; ELIXIR-ENA
Publication Year 2024
OpenAccess true
Contact blue-cloud-support(at)maris.nl
Representation
Discipline Marine Science
Temporal Coverage Begin 2018-01-01T00:00:00Z
Temporal Coverage End 2019-01-01T00:00:00Z