We request 12 days on TOSCA to study the interaction of adsorbed N2, CO2, CH4 and NO with a hydroxyl-decorated aluminium-based MOF NOTT-300. This proposed study will investigate the interactions exhibited by weakly scattering gas substrates at different loadings. NOTT-300 exhibits extremely high selectivity for CO2 and NO at ambient conditions, with high uptake capacities, suggesting the presence of specific guest/host interaction. The proposed study aims to reveal the nature of these selective gas uptake properties by analysing the guest/host interaction.