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Effect of method of preparation on the composition of complex monolayers
In the present proposal neutron reflectivity will be used in combination with contrast variation to detect changes in the presence (and size) of microdomains in monolayer films... -
Confinement and Lubrication in Liquid Crystal Films
Liquid crystals (LCs) are known to act as good lubricants, however, the reason for this remains unclear. One contributing factor is thought to be the formation of ordered layers... -
Temperature dependence of the NO3-initiated oxidation of cerebroside/fatty ac...
We will add temperature control to our reaction chamber for simultaneous neutron reflectometry(NR) and infra-red reflection absorption spectroscopy (IRRAS). This new set-up will... -
Humidity Effects on Surface Segregation in Plasticized Poly-Vinyl Alcohol Films
PVA film is widely used as a non-toxic water soluble polymer. This proposal relates to its use in unit dose detergent pouches where plasticised PVA film stores a concentrated... -
Adsorption of Organic Phosphate onto Silicon
This proposal presents to directly measure ¿bridging¿ of anionic surfactants on an anionic surface through multivalent ions from water under well-controlled conditions (pHs and... -
The Interaction of wild-type and mutant Puroindoline B with Model Bacterial M...
Bacterial and fungal infections of cereal crops pose considerable risk to food security. Pathogenic resistance to conventional fungicides and pesticides is becoming widespread... -
Elucidating molecular mechanism of membrane disruption by designed α-hel...
We have previously shown that peptides such as G(IIKK)4I-NH2 (G4) can kill bacteria and inhibit cancer cell growth whilst remaining benign to mammalian host cells. We have also... -
Nanoparticle-surfactant layers at the water-oil interface
The spontaneous selfassembly of nanoparticles (NP) at liquid-liquid interfaces is a phenomenon present in nature and relevant for many applications, such as, emulsion... -
Introducing the O-antigen into Bacterial Outer Membrane Models
The Gram negative bacterial outer membrane protects the bacterium from external toxins such as antibiotics. This is partially responsible for Gram negative bacteria becoming the... -
Adsorption of key functionality at the calcite/water interface
Calcium carbonate is one of the most abundant minerals at the Earths surface and plays a large role in the chemistry of aquatic environments, as well as being the main... -
Neutron scattering to characterise protein interactions with solid-liquid int...
Objectives of this proposal aim to shed light on how adsorption processes such as protein A chromatography, used to purify biologics, affect protein propensity for aggregation.... -
Self-assembled Floating Lipid Bilayers: What Forces Are Causing the Bilayer t...
Recently (RB19100102) we have discovered that floating bilayers composed of fluid phase lipids can be produced by deposited vesicles onto charge modified oligo(ethylene... -
Protein Adsorption at the PDMS Oil/Water Interface
Neutron reflection has been successfully used to measure the conformation of proteins adsorbed at the oil/water interface. However, in several such experiments, hexadecane has... -
Adsorption of surfactants used in fire-fighting foams
The aim is to use Neutron Reflectivity (NR) to gain essential information on adsorption properties of practical fluorotelomer surfactants used in fire-fighting foam formulations... -
Interactions between lipoprotein particles from human serum and model blood v...
In westernised societies, atherosclerosis and its clinical consequences such as heart disease and stroke constitute the leading cause of death. Thus, the prevention or... -
Self-assembling antimicrobial peptides: interactions with model lipid membranes
We propose to investigate antimicrobial peptides that self-assemble into well-defined nanostructures. Previous SAXS results have shown that the peptides form rather robust... -
Ion distribution in light-emitting electrochemical cells
Semiconducting polymers are researched as alternatives to inorganic materials for use in electronic devices, such as solar cells or organic light-emitting diodes. Polymers are... -
The mechanism of lipid transport in Gram-negative bacteria
The bacterial cell envelope is one of the best targets for antimicrobial development. It is this envelope that harbours the instruments of microbial warfare, preventing its... -
Surfactants and additives at the metal-oil interface
The lubrication of surfaces by oils is a key aspect of many academic and industrial problems with significant financial implications. In this experiment we would like to extend... -
Recreating the specific colicin NRa-LPS interaction in a model bacterial out...
The Gram negative bacterial outer membrane protects the bacterium from external toxins such as antibiotics. This is partially responsible for Gram negative bacteria becoming the...