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Unravelling the solution structures and stability of industrially-important a...
The glycosylation of glycoproteins is a major determinant of their stability, and glycans also affect their aggregatibility (precipitation). An understanding of this is... -
Rapid microfluidic phase mapping of SDS:water:butanol
Sodium dodecyl sulfate (SDS) is an anionic surfactant, extensively employed in cosmetics and personal care, as well as in pharmaceuticals and food products. Surfactants are... -
Structural development of magnetite chains
One dimensional (1D) magnetic nanostructures exhibit anisotropic magnetic properties and thereby differ from unstructured materials. However, magnetic chains are energetically... -
Competitive adsorption of a Biosurfactant conventional surfactant mixture at ...
We propose to study the competitive adsorption of a biosurfactant conventional surfactant mixture at the surface of an emulsion droplet in order to determine how these two... -
Folated derivatized nanoemulsions for the treatment of cancer
Nanoemulsions (NE) i.e. nanoparticles containing a fluid lipid or oil dispersed in water and stabilized by a surfactant particles have attracted considerable attention as... -
Structural Studies on Aggregates Formed by Novel Star-Shaped Oligomeric Surfa...
Oligomeric surfactants, where three or more alkyl chains and headgroups are connected via spacer groups with various geometries, have interesting and potentially important... -
Unravelling the solution structures and stability of industrially-important a...
The glycosylation of glycoproteins is a major determinant of their stability, and glycans also affect their aggregatibility (precipitation). An understanding of this is... -
Understanding the microstructure of polymer blends used as control release co...
Solid oral dosage forms consist of polymer layer encapsulated drug-bound particles with a desired drug release profile e.g. pulsatile, controlled, delayed and targeted,... -
Exchange kinetics of complex coacervates core micelles
Coacervates have been studied for a long time for their unusual properties: they are dense networks of charged polymers that are soluble in water. Instead of flocculating when... -
Effect of oxidation on lipid raft formation: a SANS study
The separation of particular lipids in cell membranes into liquid ordered and liquid disorder regions is thought to have a major influence of the functioning of membrane... -
Structural stability of novel anticancer hexameric fusion protein: SANS inves...
A shift towards antibody-based cancer treatments has occurred due to their ability to provide targeted cancer treatment with fewer negative side effects than traditional... -
Dynamics of amyloid protein fibril elongation using isotope-labelled SANS
This proposal combines optical spectroscopy with neutron scattering using novel labelling strategies to investigate ?amyloid? protein fibrils. Variations in packing and in the... -
Biomolecular Cryoprotection in Deep Eutectic Solvents
Protecting biomolecules, such as proteins and enzymes, from the effects of cooling and freezing is important for the storage and handling of pharmaceuticals. Deep eutectic... -
Ligand conformation at semiconductor nanoparticle surfaces for high-efficienc...
The efficiency of silicon solar cells is limited to 29%. One possible way of breaking this limit uses a process called singlet fission, converting a high energy photon into two... -
Solubilisation in Zwitterionic Micelles: Effect of Structure
The project aims to probe the relationship between surfactant structure, the micelles formed in solution, and the type of drug molecules that the micelles solubilise. Once... -
Controlling diblock co-polymer morphologies via selective solvent annealing -...
Diblock co-polymers consist of two polymer chains with different chemical properties tied together at a central linking block. The interactions between the two blocks result in... -
Using SANS to understand the structural basis for the rheology of molten choc...
Molten chocolate is a semi-solid suspension of (mostly) sugar, but also cocoa and milk solids in oil. In order to allow the sugar grains to flow past each other, either when the... -
Developing a general approach to resolution of accessory proteins bound to cl...
Endocytosis plays a central role in allowing the selective transport of molecules, via membrane-derived vesicles, into cells. Vesicle formation is controlled by a complex... -
Formulating polymer solutions to stabilise polymeric foams
Polyurethane foams (PUF) are commonly prepared by mixing Pluronic type copolymers and isocyanate reactive monomers in the presence of additives e.g. catalysts, blowing agents... -
Effect of serum and electrolyte on the structure of nanoemulsions intended fo...
Nanoemulsions (NE) i.e. nanoparticles containing a fluid lipid or oil dispersed in water and stabilized by a surfactant particles have attracted considerable attention as...