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Structure-function studies of Replication Protein A, a crucial player in geno...
Replication protein A (RPA), the eukaryotic ssDNA binding protein, is a heterotrimeric protein required for almost all aspects of cellular DNA metabolism. RPA binds... -
Visualisation of Multi-component Ion Exchange for Oil Recovery
Release of oil bound to clay minerals by exchange of bridging cations for non-bridging ones is postulated as a major mechanism for enhanced oil recovery. In this work we propose... -
Early stages of amyloid aggregate formation
We will study the kinetics of the early stages of aggregate formation in protein solutions under conditions that are known to result in the formation of amyloid protein fibres... -
Solution structures of the immunologically important proteins IgG and C3b
IgG antibody represents one-third of new drugs currently in development. We will unravel the solution structures of the Fab and Fc fragments within IgG. Following our earlier... -
Quasi-elastic neutron scattering using Neutron Spin echo
We propose a measurement of the effectiveness of using the RF flippers on Offspec in a quasi-elastic mode (theta=90°) with the RF at 0.5MHz. This is important to our future... -
SESANS study of phase segregation in microemulsion polymerisations
Spin echo small-angle neutron scattering (SESANS) beamtime is requested to study the growth of polymer nanolatices in novel microemulsion systems. The natural incompatibility of... -
The solution structure of the OmpF¿Colicin N complex in neutral detergent by ...
Gram negative bacteria cause a wide range of diseases including meningitis, bubonic plague, gonorrhoea, diarrhoea, Legionnaires' disease and cholera. Their outer membrane... -
Surfactant-Controlled Assembly of Amphiphilic Diblock Polythiophenes
Conjugated polythiophenes (PTs) have emerged as a promising class of material in organic solar cells. The device performance depends on the inherently-linked optoelectronic... -
Aggregation in ionic liquids
The aim of this experiment is to investigate surfactant aggregation in ionic liquids and also ionic liquid ¿ oil and ionic liquid ¿ water microemulsions via SANS. Contrast... -
STRUCTURE OF THE COMPLEX BETWEEN CYTOCHROME P450 REDUCTASE AND CYTOCHROME C
Cytochromes P450 play a key role in drug metabolism in man. Electrons are supplied to the cytochromes by NADPH through the flavoprotein NADPH-cytochrome P450 reductase (CPR).... -
CO2 foams stabilized by W/CO2 interfacially active hydrocarbon surfactants an...
CO2 foams can be formed in water/carbon dioxide (W/CO2) mixtures with the aid of W/CO2 interfacially active hydrocarbon surfactants and surface treated silica nanoparticles... -
Mechanism of charging metal oxide colloids in non-polar solvents
Contrast-variation SANS (CV SANS) will be used to determine how surfactant inverse micelles interact with model metal oxide colloids. By using deuterated surfactant (D-AOT) with... -
Detailed structures of surfactant micelles
Measurements are required for Sans2d resolution checks and also the overlap of the two Sans2d detectors. Proposal submitted to panel and they deemed it should be done as... -
Rates of Molecular Transfer Across Interfacial Layers Using µSR
The first direct measurements of the rate of transfer of a probe molecule across an interfacial layer have been made at PSI, using TF and ALC-MuSR. This application for beamtime... -
Comparison of Adsorbed Surfactant Behaviour under Poiseuille Flow to Cone-Pla...
As our understanding of surfactant interfacial behaviour grows it is important to assess the applicability of the results to industrial applications. In these cases there are...