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Replisome loading reduces chromatin motion independent of DNA synthesis
Chromatin has been shown to undergo diffusional motion, and during active gene transcription the RNA polymerase activity negatively affects chromatin motion. However, the... -
Developmental differences in genome replication program and origin activation
To ensure error-free duplication of all (epi)genetic information once per cell cycle, DNA replication follows a cell type and developmental stage specific spatio-temporal... -
Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicat...
Oxidation of the epigenetic DNA mark 5-methylcytosine by Tet dioxygenases is an established route to diversify the epigenetic information, modulate gene expression and overall...
