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Engineering nanoparticles for protein therapeutics - quantifying membrane acc...
The self-assembly properties of lipid systems can be exploited to form lipid membranes with complex morphologies. These include membranes with a lattice-type internal structure... -
Investigation of Folded Globular Maltose Binding Protein Based Hydrogels
We have developed a new model to describe the structural architecture of hydrogels composed of cross-linked maltose binding proteins (MBP), supported by multiple techniques... -
Partially deuterated gradient poly(2-oxazolines): self-assembly studies
Gradient and block copoly(2-oxazoline)s have been prepared comprising a partially deuterated hydrophilic poly(2-methyl-2-oxazoline) part and a hydrogenated... -
Investigating the effect of nanoparticles on PBI self assembly
The generation of hydrogen from water using light could be a method of providing a clean fuel, which is clearly important for our growing energy needs. We are using perylene... -
Polymer-Lipid Nanodisc Self-assembly Processes Using Stop Flow
Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Polymer stabilized lipid bilayer discs... -
Bulk interactions of surfactant molecules in aqueous particle suspensions
Surfactants represent an important class of compounds owing to their ability to readily locate at interfaces, be it airliquid, liquidliquid or solidliquid. As such,... -
Nanostructuring of Polyphilic Liquid Crystals
The organisation of molecules in liquid crystal phases relies on many factors, often related to space-filling considerations driven by the volume of different molecular... -
Nanoarchitecture of polyprotein hydrogels
The properties of hydrogels are defined not only by their chemical composition, but also the spatial organization of their components. Applications that require a higher level... -
Micelle structures in unequal mixtures of amino-acid surfactants
In a previous proposal we started to study the micellar structures formed from biodegradable surfactants synthesised using amino acids as the headgroups. The aim of this work is... -
Exchange kinetics of complex coacervates core micelles
Coacervates have been studied for a long time for their unusual properties: they are dense networks of charged polymers that are soluble in water. Instead of flocculating when... -
SANS study of formation of gels and foams from gelatin with metal salts
Recently, we have prepared highly active carbon catalysts for the oxygen reduction reaction in hydrogen fuel cells. These materials are synthesized easily by mixing metal... -
Investigating Nano-segregation and Structuring in Ionic Liquid Mixtures using...
It is proposed to use small-angle neutron scattering (SANS) to investigate in detail the binary phase diagram between 1-ethyl-3-methylimidazolium... -
Small-Angle Neutron Scattering studies of a bacterial colonization factor
We plan to carry out SANS experiments on a bacterial colonization factor to elucidate how it interacts with chitin, which is found on the surface of plankton and crustaceans.... -
Lipid exchange dynamics between native lipoprotein particles and human cell m...
Atherosclerosis is the primary cause of death in westernized societies. Clinical indicators include not only the net lipoprotein concentration but also the ratio between the... -
Probing the structure of polymer stabilised foams
Polyurethane foams (PUFs) are commonly prepared by mixing Pluronic type copolymers and isocyanate reactive monomers in the presence of additives e.g. catalysts, blowing agent... -
Micelle structures in mixtures of amino-acid surfactants
There has been a recent revival of interest in preparation of surfactants from natural starting materials as they are more biodegradable and thus more environmentally friendly... -
Particle formation mechanism for overbased calcium carbonate particles stabil...
Approved proposal under the ICRD Scheme Proposal ICRD0006 -
Structure and interactions in model and real anti-reflective coatings
This proposal seeks to exploit contrast variation SANS to study a multi-component system, spanning a wide range of colloidal length scales. The multi-component system under... -
Kinetics of amphotericin B interaction with model human and fungal cell membr...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents. The successful development of... -
Aggregation of random co-polymers
This proposal builds upon the successful study of a cationic copolymer capable of forming polymer micellar-like aggregates, simply by reducing pH (D33 at ILL 9-12-433 see...