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SANS study of lipid-based nanocarriers as inhaled drug delivery systems for a...
The present project aims to achieve a more detailed structural characterization by SANS of Solid Lipid Nanoparticles (SLN) and liposomes in a perspective of an inhaled anti... -
Understanding the properties of phosphlipid-homopolymer self assembles
We hope to explore the self assembly properties of a novel chain end functionalised homopolymer to better understand its structure and enable tuning of its properties to enable... -
Ionic liquid containing microemulsions
The aim of this experiment is to characterise several novel ionic liquid ¿ oil and ionic liquid ¿ water microemulsions via SANS prior to their use in the synthesis of metallic... -
Formation of cellulose-starch gels: effect of cellulose source and surfactants
This proposal forms part of an ongoing project concerning interpenetrating network gels of starch and cellulose being developed towards applications in personal care and... -
Reconstitution of human dihydroorotate dehydrogenase into lipid-detergent mic...
Human dihydroorotate dehydrogenase (DHODH) is an integral membrane protein found in mitochondria involved in the biosynthesis of pyrimidines. DHODH oxidizes dihydroorotate with... -
Silk fibrillogenesis: Morphology, structure and hydration of the intermediate...
At the heart of protein¿s aggregation are specific molecular events; and how they are modulated by changes in solvent conditions is key to our understanding and control of... -
Domain patterning in bicontinuous cubic lipid phases
Dynamic microdomains, resulting from lateral lipid inhomogeneity and patterning within biological membranes, have been implicated in a wide range of critical cellular processes... -
Calcium and pH induced changes in silk solutions
Spider silks are known to have outstanding mechanical properties yet there is still much unknown about how the initial structure, storage and transformation of the silk proteins... -
Cross-linked Electrospun Fibres containing Cellulose
In this proposal we shall explore the nature of electrospun fibres produced from blends of cellulose and polystyrene which we shall use as a model to develop high strength... -
Structure of oil-in-water microemulsions containing eutectic mixtures of ment...
Although microemulsions have been widely investigated as potential drug delivery vehicles, relatively little work has been performed establishing the detailed molecular... -
Aggregation behaviour of PEGylated ibuprofen
In the present study the acidic, anti-inflammatory drug, ibuprofen has been PEGylated using an polyoxyethylene chain of 750 molecular weight. The consequence of this PEGylation... -
pH-Sensitive Dendrimers
Dendrimers are nanosized macromolecules with hyperbranched structures that are capable of loading all kinds of active agents for biodelivery. They are monodisperse in terms of...
