56 datasets found

Within a biological system such as a cell or tissue, water structure and dynamics are known to be changed by the presence of biomolecules or extrinsic entities (e.g. drugs),...

Abnormally glycosylated IgA leads to IgA nephropathy, the most common cause of renal failure. IgG antibody represents one-third of new drugs currently in development, and its...

Exposure to ozone gas can cause inflammation of the airways and breathing difficulties. The initial reaction of ozone is thought to be predominantly with lipids present in the...

Cell adhesion and proliferation at the surface of liquids such as oil droplets is a surprising phenomenon as it is typically accepted in the field of bioengineering that cells...

This proposal is about the development of sustainable detergency based formulations, based on the blending of biosurfactants with conventional surfactants, and is part of a CASE...

Many biological processes occur at the interface of cells, at the so called cell membrane, such as internalization of biological nanoparticles, including virions, exosomes and...

In the proposed experiments we aim to characterise the structures of aggregate species formed when divalent metal ions, such as calcium(II), interact with the anionic conjugated...

Of concern to the bioprocessing industry is the manner in which polysorbates included in solution formulations of antibodies affect the kinetics and equilibrium state of...

Water dynamics plays a vital role in biochemical processes in a living organism. Intracellular water structure and dynamics are known to be changed by the presence of...

Controlled vesicle fusion has major advantages in diagnostic and drug delivery applications. We have designed a DNA hybridisation-based assay for directed fusion of vesicles...

Cyclic peptide-polymer conjugates can readily self-assembly into long nanotubes, and are being extensively studied for drug delivery applications. Recently, using SANS and...

Aggregates of the cationic conjugated polyelectrolyte (CPE) HTMA-PFP with poly(vinyl alcohol) (PVA) will be studied in aqueous solutions using SANS. Previous fluorescence,...

Lipopeptide surfactants are highly effective at reducing interfacial tension. However, there is a general lack of understanding of the relationship between their molecular...

We are unravelling the solution structures of the Fab and Fc fragments in the IgA antibody family important in mucosal immunology. Having completed the structures for IgA...

Mitochondria are not only the powerhouse of the cell, but are also involved in cellular suicide via apoptosis (programmed cell death). The mitochondrial apoptotic pathway is a...

Lipopeptide surfactants are highly effective at reducing interfacial tension. However, there is a general lack of understanding of the relationship between their molecular...

This proposal seeks to gain an understanding of the adsorption and desorption behaviour of a redox membrane protein, cytochrome c, in electrochemical cells using different anode...

Cyclic peptide-polymer conjugates can readily self-assembly into long nanotubes, and are being extensively studied for biomedical applications. Recently, we have conjugated a...

This proposal constitutes part of our ongoing study towards understanding the adsorption of collagen based polypeptide and its interaction with ionic surfactants at the...

IgG antibody represents one-third of new drugs currently in development. We will unravel the solution structures of the Fab and Fc fragments within IgG. Following our earlier...