56 datasets found

We have previously shown that peptides such as G(IIKK)4I-NH2 (G4) can kill bacteria and inhibit cancer cell growth whilst remaining benign to mammalian host cells. We have also...

Adsorption of a charged polyelectrolyte onto an oppositely charged substrate is important for the understanding of many natural molecular events as well as for the development...

The understanding of the plant wax-surfactant interaction process is crucial to the development of more effective pesticide and fungicide formulations, essential for improving...

Water plays a vital role in biochemical processes in a living organism. Within a cell, intracellular water structure/dynamics are known to be changed by metabolites or extrinsic...

Nonionic surfactants usually do not show affinity to proteins and they work via competitive surface and interfacial processes in a binary mixture with protein. However, we show...

The insertion of peptides and proteins into cell membranes is crucial for the functioning of cells, and also for the functioning of a variety of antibacterial reagents. Cells...

Small angle neutron scattering (SANS) will be used to characterise the structures of aggregates formed between the anionic conjugated polyelectrolyte...

Mica is an exceptionally important mineral in surface science, which until now has been inaccessible by neutron reflection. Here we propose a novel attachment method unlocking...

Abnormally glycosylated IgA leads to IgA nephropathy, the most common cause of renal failure. IgG antibody represents one-third of new drugs currently in development, and its...

Hydrophobins, hfb2, are secreted fungal proteins, which are strongly surface active and possess powerful emulsion and foam stabilising properties. Understanding their...

Atherosclerosis and subsequent clinical complication is one of the biggest killers in the western world, with a death toll reaching 16.7 million deaths per year. Although many...

Cell adhesion and proliferation at the surface of liquids such as oil droplets is a surprising phenomenon as it is typically accepted in the field of bioengineering that cells...

Previous SANS studies of anti-cancer polymer-drug conjugates (PDCs) (HPMA-Doxorubicin) identified a correlation between conjugate solution conformation and clinical results. The...

Acyl L-Carnitines are a group of novel surfactants with attractive physical and biological properties associated with their head group charge features. This work proposes to use...

This work aims to exploit the unique capability of neutron reflection to examine how 2 antimicrobial lipopeptides that tend to adopt different secondary structures bind to model...

Thermoresponsive gels are widely used for tissue engineering and drug delivery applications. They consist of a thermoresponsive polymer that self-assembles in a 3D network when...