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Effects of increased CO2 on fish gill and plasma proteome
Ocean acidification and warming are both primarily caused by increased levels of atmospheric CO2, and marine organisms are exposed to these two stressors simultaneously.... -
(Table A.3) BLAST-unique proteins
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(Table A.2) Identified proteome based on sturgeon database
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(Table A.1) Identified proteome based on zebrafish database
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Investigation of the dynamic nature of proteins with enhanced sampling techni...
In dieser Arbeit werden zwei Aspekte der dynamischen Natur von proteinen mit Hilfe von Enhanced Sampling Methoden untersucht. Zunächst wurden... -
Molecular architecture of novel, trichain-containing vectors for gene delivery
We have recently developed novel ternary lipopolyplex vectors (i.e. gene delivery vectors containing cationic lipid, plasmid DNA and a cationic peptide) in which, for the first... -
Elucidating the microstructure of dipeptide-based gelators
Dipeptide-based gelators can form hydrogels at low concentrations using a number of means. We have found that the method by which the gels are formed can have a profound effect... -
Further Studies on the Gating Mechanism of an Antimicrobial Peptide Using Con...
Antibiotic peptides are generally small, simple, usually alpha-helical peptides, which nevertheless show quite complex biological behaviour. We have been studying the gating... -
A SANS Study of Hydration Shell and Magnetic Field Alignment of Amyloid Pepti...
We will perform neutron scattering experiments (SANS) to probe the mechanism of alignment of amyloid peptides on drying in the presence of a 2T magnetic field, as well as the... -
Surface Layer Structures of Short Peptide Amphiphiles
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly, leading to interfacial adsorption and solution nano-aggregation.... -
Interaction of keratin with surfactants studied by SANS
This proposal constitutes part of our ongoing study towards understanding how keratin, an important protein component of hair and skin, interacts with ionic surfactants using... -
Antimicrobial Peptide Binding & Rearrangement in Model Membranes ¿ Building a...
Antimicrobial peptides (AMPs) are attractive drug candidates because of their selectivity and speed of action against bacteria. We have developed a novel approach to delivering... -
Insertion of antimicrobial peptides into phospholipid monolayers at air/liqui...
We have designed a series of cationic peptides with different helix repeats that can kill bacteria but remain benign to mammalian host cells. The selectivity to cell types is... -
Solution Aggregation of Short Peptide Amphiphiles
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly, leading interfacial adsorption and solution nano-aggregation.... -
Using SERGIS to characterise monolayer buckling on the approach to collapse
Thin films just one or a few molecules thick can play an important role in controlling many important phenomena. This includes the lipid monolayers that coat the surface of our... -
Peptide resistance in asymmetric MRSA-mimetic vesicles
We have been investigating the influcence of the cationic staphylococcal lipid lysyl-phosphatidylglycerol (L-PG) on bacterial resistance to antimicrobial peptides (AMPs). Using... -
Intermediate Structures formed during the aggregation of the Amyloid beta Pep...
The aggregation of the Amyloid beta (Abeta) peptide is implicated in the progression of Alzheimer's disease, the treatment of which is a major current global healthcare... -
Self-assembly of detergent molecules below ambient temperature: SANS to deter...
Although surfactant detergency is well understood above 30 C, actions of surfactants below 30 C are not well established. In the era of energy saving and environment caring, we...
