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Direct mapping of higher-order RNA tertiary interactions by SHAPE-JuMP
Higher-order structure governs function for many RNAs. However, discerning this structure, especially for large molecules, is a challenging and unresolved problem. Here, we... -
Nano-DMS-MaP allows isoform specific RNA structure determination
Genome-wide measurements of RNA structure can be obtained using reagents that react with unpaired bases, leading to adducts that can be identified by mutational profiling on... -
Condylostoma magnum Transcriptome or Gene expression
Single cell transcriptome sequencing of microbial eukaryotes -
High-throughput parallel imaging and single-cell transcriptomics of microbial...
In this study we applied MASC-seq (massive and parallel microarray sequencing, https://doi.org/10.1038/ncomms13182), a scRNA-seq method that facilitates sequencing of thousands... -
MalariaGEN
MalariaGEN aims to bring together malaria genetics with epidemiological information across both time and space. The project has two distinct but complementary goals to simplify... -
Determination of isoform-specific RNA structure with nanopore long reads
Current methods for determening RNA structure with short-read sequencing cannot capture most differences between distinct transcript isoforms. Here, we present RNA structure... -
Critical assessment of DNA adenine methylation in eukaryotes using quantitati...
The discovery of N6-methyldeoxyadenine (6mA) across eukaryotes led to a search for additional epigenetic mechanisms. However, some studies have highlighted confounding factors...
