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Virulence shift in a sexual clade of Type X Toxoplasma infecting Southern Sea...
How virulent protozoal pathogens capable of causing overt disease are maintained in nature is an important paradigm of eukaryotic pathogenesis. Here we used population genetics... -
Whole genome sequencing of T. gondii CZ clone H3
Toxoplasma gondii is a zoonotic parasite from the phylum Apicomplexa. It occurs worldwide and the current estimate of human infection is 30%. Whilst human infection with T.... -
Toxoplasma gondii PRU and PP2A-C mutation Transcriptome or Gene expression
Transcriptome of tachyzoites and bradyzoites -
Transcriptional signatures of clonally derived Toxoplasma tachyzoites
Toxoplasma gondii has numerous, large, paralogous gene families that are likely critical for supporting its unparalleled host range: nearly any nucleated cell in almost any... -
A plant-like mechanism coupling m6A reading to polyadenylation safeguards tra...
In this study, we report on our findings in T. gondii of an m6A-dependent 3’end polyadenylation serving as a transcriptional barrier at certain loci such as stage-specific... -
Transcriptome analysis of cytotrophoblasts and syncytiotrophoblasts derived f...
We tested the relevance of an established stem-cell-derived model of trophoblast development to Toxoplasma gondii infection. Human trophoblast stem cells were cultured under... -
CRISPR-Cas9 screens to identify regulators of differentiation in Toxoplasma g...
Targeted gRNA screen against putative nucleic-acid binding proteins in a differentiation reporter strain context. By looking for gRNAs enriched in parasites no longer able to... -
Toxoplasma gondii Raw sequence reads
Transcriptome analysis of TgAP2IX-5-depleted parasites -
Toxoplasma gondii Genome sequencing
The recombinant progeny of a genetic cross between monomorphic ChrIa harboring strain ME49 and divergent ChrIa harboring strain VAND were whole genome sequenced using Illumina... -
Long read sequencing of Toxoplasma gondii and its relatives
Using 3rd generation long read sequencing to refine the karyotype and interspecies synteny of Toxoplasma gondii and its near relatives. -
The transcriptome data analysis of ME49 and ME49 Delta 6pgdh1
To compare the gene expression difference between ME49 strain and ME49 Delta 6pgdh1 strain -
Single cell mapping of the Toxoplasma gondii lytic cycle gene expression and ...
scATAC-seq atlas of T. gondii, the first apicomplexan for which this is established.</p><p>2. Established map of cell cycle progression regulation events at... -
T. gondii Genome Wide CRISPR Screen for Fitness-Conferring Genes
We provide examples of the next-generation sequencing results obtained after analyzing sgRNAs (single guide RNAs) isolated from an input library and from parasites three... -
Translation initiation factor eIF1.2 promotes Toxoplasma stage conversion by ...
The parasite Toxoplasma gondii persists in host organisms by converting from replicating tachyzoites to latent bradyzoites housed in tissue cysts. The molecular mechanisms that... -
A splitCas9 phenotypic screen in Toxoplasma gondii identifies proteins involv...
Apicomplexan parasites, such as Toxoplasma gondii, have specific adaptations that enable invasion and exit from the host cell. Owing to the phylogenetic distance between... -
Effect of depleting BFD1-regulated gene-expression factors (TGME49_253790, TG...
The transcription factor BFD1 is the master regulator of the Toxoplasma chronic-stage differentiation program, which is induced under alkaline stress. Prior work indicated that... -
Depletion of m6A writers and readers impair 3'-end formation in Toxoplasma
Toxoplasma gondii is an obligate intracellular parasite that can cause serious opportunistic disease in the immunocompromised or through congenital infection. To progress... -
Genome-wide mapping of transcription initiation in the asexual stages of Toxo...
The lack of a comprehensive map of transcription start sites in Toxoplasma gondii has impeded advances in decrypting the molecular mechanisms underlying the regulation of gene... -
Toxoplasma gondii Transcriptome or Gene expression
We infected murine bone marrow-derived macrophages with 25 distinct Toxoplasma strains and generated host and parasite gene expression profiles using high-throughput RNA-seq. -
Toxoplasma gondii Raw sequence reads
Toxoplasma gondii Genome-wide CRISPR/Cas9 screen sequencing