91 datasets found

The self-assembly properties of lipid systems can be exploited to form lipid membranes with complex morphologies. These include membranes with a lattice-type internal structure...

We have developed a new model to describe the structural architecture of hydrogels composed of cross-linked maltose binding proteins (MBP), supported by multiple techniques...

Conjugation of therapeutic proteins to polymers is well established but most methods result in multi-site and multiple conjugation or crosslinking resulting in lack of...

The generation of hydrogen from water using light could be a method of providing a clean fuel, which is clearly important for our growing energy needs. We are using perylene...

Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Polymer stabilized lipid bilayer discs...

The very heterogeneous, but non-random, arrangement of lipids and proteins in cell membranes are of major scientific interest and led Simons and Ikonen to propose that ¿rafts,¿...

Hydrophobins, hfb2, are secreted fungal proteins, which are strongly surface active and possess powerful emulsion and foam stabilising properties. Understanding their...

Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Polymer stabilized lipid bilayer discs...

Surfactants represent an important class of compounds owing to their ability to readily locate at interfaces, be it air–liquid, liquid–liquid or solid–liquid. As such,...

One dimensional (1D) magnetic nanostructures exhibit anisotropic magnetic properties and thereby differ from unstructured materials. However, magnetic chains are energetically...

The organisation of molecules in liquid crystal phases relies on many factors, often related to space-filling considerations driven by the volume of different molecular...

Liposomes are lipid-based, water-filled vesicles with wide-ranging applications in diagnostics and drug delivery. Phospholipases (PLs) are enzymes that cleave specific bonds in...

The dynamic aspects of solubilisation of oils into surfactant systems, often forming microemulsions, are only little known so far, despite their importance for optimising...

The project is to understand fundamental structure-performance relationships of chemical demulsifiers in water-in-crude oil (w/o) systems. In particular, to understand how...

The properties of hydrogels are defined not only by their chemical composition, but also the spatial organization of their components. Applications that require a higher level...

The present proposal concerns a PEGylated, hydrophobic drug containing polylysine dendrimer that demonstrates unexplained batch-to-batch variability in that two batches of the...

It is well established that the anisotropy of nanoparticles has a dominant effect on increasing their uptake by cells. However, the advantage of anisotropy for cell penetration...

Competitive interaction exist in many formulations, especially in the case of hydrophobically modified polymers (HMPs), surfactants, and particles of differing surface...

Complexes prepared from cationic, dichain lipid (L) vesicles, positively chargely targeting peptides (P) and negatively charged DNA (D) or siRNA (R), known as LPDs and LPRs...

In a previous proposal we started to study the micellar structures formed from biodegradable surfactants synthesised using amino acids as the headgroups. The aim of this work is...