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Interaction of polypeptides with surfactants: SANS study of solution aggregation
This proposal constitutes part of our ongoing study towards understanding the solution aggregation of collagen based polypeptides and their interactions with model surfactants.... -
Aggregation phenomena inside polymer brushes: lateral structure
We will use off-specular reflectivity to probe the characteristic lateral length-scales in responsive polyelectrolyte brushes grown by surface-initiated ATRP from solid-liquid... -
Biosurfactant conventional surfactant mixing. Where nature does it better ?
Biosurfactants are becoming more commonplace in pharmaceuticals, vaccines and other forms of medicines. With the biobased economy growing substantially and pressure to reduce... -
Kinetics of surfactant multilayer formation / dissolution at interfaces
The formation of multilayer structures at surfaces and interfaces from self-assembly in mixed surfactant and in polymer / surfactant mixtures has been recently reported, and... -
Competitive adsorption of a Biosurfactant conventional surfactant mixture at ...
We propose to study the competitive adsorption of a biosurfactant conventional surfactant mixture at the surface of an emulsion droplet in order to determine how these two... -
Surface structure of ethoxylated PEI/SDS mixtures: optimising surface properties
The strong interaction between polyelectrolytes and ionic surfactants can result in pronounced surface adsorption and the formation of surface multilayer structures. This... -
Modification of an adsorbed cationic layer by anionic surfactants below the CMC
In this proposal, we request beamtime to study the unexpected behaviour of a strongly bound bilayer of the cationic surfactant didodecyldimethylammonium bromide on the anionic... -
Interfacial structures and competitive adsorption of amphiphilic millipede po...
Foam stability, appearance and functionality is governed by the thin liquid films between foam bubbles. These films are stabilised by surface active molecules (surfactants and... -
Ibuprofen containing surfactant monolayers: location and stiochiometry of ibu...
An increasing number of potential drug molecules are extremely water insoluble, limiting their commercialisation as medicines. Solubilisation of drug in surfactant micelles is a... -
Solution aggregation of short peptide amphiphiles
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly to lead to interfacial adsorption and solution nano-aggregation.... -
interaction of a pharmaceutical water-soluble polymer with bio-relevant surfa...
We have been developing hydroxypropylmethyl cellulose (HPMC) microspheres for delivering poorly water-soluble drugs. The in vitro dissolution data showed that the presence of... -
Interfacial conformation of antibody and antigen binding capacity
Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element... -
Surface properties of biogenic polyamine-surfactant mixtures
Polyions and biogenic polyamine are ubiquitous in many important biochemical functions. We propose here to use neutron reflectivity to investigate their potential to induce and... -
D2O Vapour Diffusion at the Air Water Interface
A theoretical estimate of the H/D exchange rate for an open trough (e.g. D2O in ambient atmosphere, 50% relative humidity) yields an amount of exchanged liquid of the order of... -
Location of the lipophilic drug testosterone propionate at the oil-water inte...
Solubilisation of poorly-water soluble drug in surfactant micelles is an attractive means of increasing the apparent aqueous solubility of such drugs in order to administer the... -
Polymer conjugates for drug delivery
Complex polymer architectures such as comb polymers have been studied for their highly customisable chemical properties. Potential applications have been identified in a wide... -
Interaction of keratin with surfactants studied by SANS
This proposal constitutes part of our ongoing study towards understanding how keratin, an important protein component of hair and skin, interacts with ionic surfactants using... -
Surfactant Segregation in Plasticised PVA
PVA film is widely used as a non-toxic water soluble polymer. This proposal relates to its use in unit dose detergent pouches where plasticised PVA film stores a concentrated... -
Can surfactants be pushed out of polymer layers by applying compression?
For many applications such as paints, foods and drug formulations, aggregation of colloidal particles is prevented by combining polymer and surfactant adsorption. Key to this... -
Interaction of polypeptide with surfactant on the surface of water
This proposal constitutes part of our ongoing study towards understanding the adsorption of collagen based polypeptide and its interaction with ionic surfactants at the...