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Ligand induced changes of the 18kDa translocator protein in a lipid bilayer
The proposed experiments will investigate conformational changes of the 18kDa translocator protein (TSPO) in a lipid bilayer using neutron reflectometry at the solid-liquid... -
The calcuim mediation interaction of DNA with monolayers of DSPC and DOPE
The main objective of the present work is to complete some work aimed at gaining an understanding of the interaction of phospholipid membranes containing the neutral helper... -
Adsorption of concentrated Aerosol-OT to Sapphire ¿ the effect of divalent sa...
AOT is also known to be very sensitive to the concentration and nature of counter-ions. When adding a sufficient amount of divalent salt to an AOT solution, a very strong Bragg... -
Phospholipid exchange between tethered bilayers and vesicles
Our objective is to create asymmetric solid surface tethered bilayers (tBLMs) with the the outer leaflet predominately populated by charged phospholipids. tBLMs are produced by... -
Conformational changes on interaction of cytochrome c with lipid monolayers.
The main objective of the present work is to gain an understanding of the interaction of the cationic protein, cyt c with anionic lipid membranes. This objective will be... -
Binding of DNA to Model Membranes in the Presence of Ca2+ Ions and a Membrane...
The aim of the present work is to gain an understanding of the interaction of DNA with the phospholipid bilayers. The effect of different forms of DNA, the presence of divalent... -
Using Magnetic Contrasts to Establish the Mechanism and Kinetics of Lipid Fli...
In order to maintain their asymmetric lipid distribution, cellular membranes have a number of means to translocate lipid molecules across the bilayer. On top of the well-studied... -
Structural study on the 3D arrangement of (hexa-acyl) lipid A in lipid membrane
This study will focus on the structural investigations of the bilayers formed on silicon substrates in which the outer leaf consists of DOPE/LPS mixtures. We aim is to achieve... -
Intra-membrane lipid flipping in model lipid membranes
Lipid compositional variation across the cell's membranes as well as asymmetry between two contiguous monolayers in the same membrane are critical for alive and healthy cells....
