Gram negative (-ve) bacteria possess numerous defenses against antibiotics, not the least of them being the intrinsic permeability barrier afforded by their outer membrane (OM) and various efflux mechanisms which pump out drugs. A novel compound was synthesized at the KCL which shows promising activity against Gram (-ves). However, there was a noticeable effect of drug efflux resulting in reduced efficacy. This project investigates novel formulations to increase OM permeability to the antibiotic. Drug/enhancer complexes were made, which pass into the cell and dissociate thereby circumventing intrinsic resistance and membrane-associated efflux mechanisms. Neutron reflectivity will offer a greater insight into the intimate molecular drug (pure and formulated)-membrane interactions in order to understand how drug uptake may be improved for achieving optimal antimicrobial activity