A 9-month aquarium experiment with the cold-water coral Dendrophyllia cornigera was conducted to investigate the single and combined effects of warming, acidification, and deoxygenation on its ecophysiological response. The experiment took place at the Aquarium finisterrae (A Coruña, Spain) between 2022-05-06 and 2023-02-24. Treatment values for each parameter (current in situ vs. climate change) were: 12 °C and 15 °C (temperature); ~7.99 and 7.69 (pH); ~8.63 mg/L and 6.45 mg/L (dissolved oxygen concentration). A total of eight treatments (with 3 replicates each, 5 L aquaria) were set up. Tissue surface area was assessed using photogrammetric analyses on 3D reconstructions of each nubbin at the beginning of the experiment and after 6 and 9 months (181 and 267 days, respectively). 3D models of each nubbin were performed using Agisoft Metashape Professional v. 2.0.2 (Agisoft PhotoScan Professional, 2021) and following the methodology applied by Bilan et al. (2023). Tissue surface quantification (mm2) was performed using MeshLab (Cignoni et al. 2008). Tissue extension for each nubbin was calculated as the slope of the linear regression between the logarithmically transformed tissue surface area and the experimental time, and expressed as % d-1.