mRNA-Seq of Myriophyllum spicatum exposed to low-effect concentrations of the herbicide bentazone and the pharmaceutical atorvastatin against untreated control groups

Within this study, the non-model organism Myriophyllum spicatum was used to evaluate ecotoxic modes of action at the gene expression level. M. spicatum was exposed to low-effect concentrations of bentazone and atorvastatin in a shortened and modified version of the OECD guideline test No. 239, followed by RNA extraction of the shoot tip tissue and a subsequent RNA-seq analysis utilizing a de novo assembly of the transcriptome. While the herbicide bentazone is an inhibitor of photosynthesis, the widely spread pharmaceutical atorvastatin acts as an inhibitor of the hydroxymethylglutaryl-CoA reductase and thus the isoprenoid biosynthesis. The aim of this study was to determine molecular fingerprints and biomarkers distinguishing these distinct modes of action at a molecular level.

Identifier
Source https://data.blue-cloud.org/search-details?step=~012F9E15AFDD1AE4F38044BF36681D9BDF53EDEEDFF
Metadata Access https://data.blue-cloud.org/api/collections/F9E15AFDD1AE4F38044BF36681D9BDF53EDEEDFF
Provenance
Instrument Illumina NovaSeq 6000; ILLUMINA
Publisher Blue-Cloud Data Discovery & Access service; ELIXIR-ENA
Contributor European Bioinformatics Institute;Department Ecotoxicogenomics;Fraunhofer Institute for Molecular Biology and Applied Ecology IME
Publication Year 2024
OpenAccess true
Contact blue-cloud-support(at)maris.nl
Representation
Discipline Marine Science