Understanding the interfacial behaviour of bile salts to better engineer lipid emulsions: small-angle neutron scattering measurements
The current project aims to 1) elucidate how bile salts (BS) structure influences their interfacial behaviour and role during lipolysis; 2) to study the potential ability of specific food emulsifiers to inhibit BS adsorption, and thus lipase adsorption, at the lipid/water interface. Small-angle neutron scattering beam time is requested here to investigate BS self-assembly in the bulk and to characterise the structure of emulsion droplet interfaces stabilised by food emulsifiers, after interaction with BS and lipase/co-lipase. Two structurally different BS showing contrasting interfacial behaviours have been selected in this work. Three methylcelluloses are chosen as emulsifiers due to their demonstrated cholesterol-lowering capacity. BS adsorption at droplets interfaces will be studied and equilibrium structures after interaction with lipase measured, as a function of BS type and amount.
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Provenance | |
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Creator | Miss Suzette Lust; Ms Tong Yu; Professor Peter Wilde; Dr Isabelle Grillo; Dr Olivia Pabois; Dr Richard Harvey; Dr Najet Mahmoudi; Dr Cecile Dreiss |
Publisher | ISIS Neutron and Muon Source |
Publication Year | 2021 |
Rights | CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/ |
OpenAccess | true |
Contact | isisdata(at)stfc.ac.uk |
Representation | |
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Resource Type | Dataset |
Discipline | Chemistry; Natural Sciences |
Temporal Coverage Begin | 2018-02-14T09:00:00Z |
Temporal Coverage End | 2018-02-19T09:00:00Z |