Hydrophobic drug encapsulation is one of the widely used strategies to overcome the poor adsorption and bioavailability of these drugs in vivo. Water-soluble amphiphilic copolymers such as Pluronic tri-block copolymers have been studied extensively over recent years, in particular, for their potential as drug delivery agents. These polymers are able to encapsulate and increase the aqueous solubility of poorly water-soluble drugs due to formation of micelles in aqueous solutions above their critical micellar concentration (CMC) and temperature (CMT). We propose investigating changes in aggregate size and structure of the copolymer-flurbiprofen solutions at various temperatures and pH values. Changes in aggregate size and structure are critical in predicting the polymeric drug release patterns in the body.