The purpose of this study was to connect some conceptual dots surrounding the use of normality by regressing a person’s acceptance of normality as being applied in medicine on theoretically derived predictor variables. Our analysis tackles the question of which socio-demographic, personality-related, or morality-related variables go hand-in-hand with normality in people’s minds in real-world-settings. Thus, this study sought to (a) elucidate people’s (lay persons’ and medical professionals’) understanding of normality in medicine and, based on this, to (b) identify concepts that are linked to the concept of normality.