Understanding the interaction between antimicrobial peptide-loaded lipid particles with bacteria mimicking membranes

DOI

The number of antibiotic-resistant bacteria is increasing worldwide, and the demand for novel antimicrobials is constantly growing. Antimicrobial peptides (AMPs) could be an important part of future treatment strategies of various bacterial infection diseases. However, AMPs have relatively low stability, because of proteolytic degradation. As a consequence, carrier systems protecting the AMPs are greatly needed, to achieve efficient treatments. Dispersions of lipid-based liquid crystalline nanoparticles (cubosomes) are biocompatible drug delivery vehicles, well suited for delivery and protection of AMPs, due to their ability to encapsulate amphipathic molecules. However, the bacterial membrane disruptive properties of the AMP-loaded cubosomes remains unclear, but can be studied using neutron reflectivity.

Identifier
DOI https://doi.org/10.5286/ISIS.E.92922658
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/92922658
Provenance
Creator Miss Randi Nordström; Ms Liv Sofia Elinor Damgaard; Dr Kathryn Browning; Mr Lukas Boge; Dr Arwel Hughes; Professor Martin Andersson
Publisher ISIS Neutron and Muon Source
Publication Year 2021
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Medicine
Temporal Coverage Begin 2018-05-14T08:00:00Z
Temporal Coverage End 2018-05-17T08:00:00Z