The dataset comprises fractional abundances of individual isoprenoid and branched glycerol dialkyl glycerol tetraethers (GDGTs) and C37 alkenones of samples from the past 1 Ma at Site 350-U1437 relevant for the calculation of the TEX86 (tetraether index based on glycerol dialkyl glycerol tetraethers consisting of 86 carbon atoms), methane index (MI), branched and isoprenoid tetraether index (BIT), and the unsaturated ketone index (UK'37), respectively. The ketone-bearing fractions were measured on an Agilent 7980 GC coupled to an Agilent 5975 MS (Agilent, Germany). The polar fractions were analyzed by high performance liquid chromatography coupled to mass spectrometry (HPLC/MS) using an Alliance 2690 HPLC (Waters, UK) and a Quattro LC triple quadrupole MS (Micromass, UK) to measure glycerol dialkyl glycerol tetraethers (GDGTs).