Intracellular spinal recordings: patch-clamp and dorsal root evoked excitatory post-synaptic currents

DOI

Intracellular recording dataset from spinal motoneurons associated with Pocratsky et al 2023, Science Translational Medicine

Data generated from isolated postnatal spinal cord preparations with dorsal roots attached (postnatal day 1-13). Groups: littermate controls (Cdx2::wt;Tor1a-wt/frt) and spinal Tor1a d-cko mice (Cdx2::FlpO;Tor1a-frt/frt) that develop early onset generalised torsional dystonia. 

Intracellular_recordings.xlsx - dataset: intrinsic lumbar spinal motoneuron properties and dorsal root-evoked excitatory post-synaptic currents (EPSCs)

210616_DIC_lumbarMNs_P9-control.nd2: differential interference contract (DIC) image of lumbar motoneuron pool in control mouse

210616_DIC_lumbarMNs_P9-spinalTor1aCKO.nd2: DIC image of lumbar motoneuron pool in spinal Tor1a d-cko mouse

Full methodological detail can be found in manuscript

Identifier
DOI https://doi.org/10.5522/04/19649871.v1
Related Identifier https://ndownloader.figshare.com/files/34894500
Related Identifier https://ndownloader.figshare.com/files/34894518
Related Identifier https://ndownloader.figshare.com/files/34894521
Metadata Access https://api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:figshare.com:article/19649871
Provenance
Creator Pocratsky, Amanda; Do Nascimento Xavier Fernandes, Filipe; Ozyurt, Gorkem; White, Ian; Sullivan, Roisin; O'Callaghan, Benjamin; Smith, Calvin; Surana, Sunaina; Beato, Marco; Brownstone, Rob
Publisher University College London UCL
Contributor Figshare
Publication Year 2023
Rights https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact researchdatarepository(at)ucl.ac.uk
Representation
Language English
Resource Type Dataset
Discipline Life Sciences; Medicine; Neurosciences