Domain patterning in bicontinuous cubic lipid phases

DOI

Dynamic microdomains, resulting from lateral lipid inhomogeneity and patterning within biological membranes, have been implicated in a wide range of critical cellular processes ranging from cell death and disease mechanisms, to signalling. While there has been significant research into lateral phase separation in flat lamellar membranes, little is known on phase separation and patterning in curved lipid phases. Non-lamellar lipid phases are known to play important roles in-vivo and have attracted enormous interest as biocompatible scaffolds in applications form drug delivery to membrane protein crystallisation. Here we aim to locate preferential partitioning of high and low bending moduli liquid phases to the flat and curved (saddle) points within bicontinuous cubic phases respectively. This will be vital to unlocking our ability to exploit the biotechnical potential of these structures.

Identifier
DOI https://doi.org/10.5286/ISIS.E.87761446
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/87761446
Provenance
Creator Professor John Seddon; Dr Nick Brooks; Dr Sarah Rogers; Dr Robert Law; Dr Arwen Tyler; Dr Oscar Ces; Dr Peixun Li; Dr Adam Squires; Mr Ben Eves; Miss Eleonore Mason
Publisher ISIS Neutron and Muon Source
Publication Year 2020
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Natural Sciences
Temporal Coverage Begin 2017-09-25T08:00:00Z
Temporal Coverage End 2017-09-27T13:00:21Z