Building from work previously carried out at ISIS (RB1410544) and pulished open-access in Chem. Commun. 2016, 25, 7344, we propose a SANS experiment to investigate the structure of droplets of a highly fluorescent liquid pyrene dispersed in water using various biocompatible surfactants. These systems have shown promise as replacements for nanoparticle or solubilised dye dispersions in biomedical fluorescent imaging (in-vitro or in-vivo). Knowing how parameters such as temperature and composition alter the droplet size and shape will allow us to tune the fluorescent properties and may allow targeting of specific biological regions for imaging.