Although the circulation of the western South Atlantic tightly controls the meridional heat and salt transport, our knowledge about its long-term past changes is still fragmented and sparse. While many studies focused their attention on the last glacial and deglaciation periods, Holocene studies mostly lack of an integrated analysis from the subtropical and midlatitude regions. The analysis of selected regionally distributed paleoceanographic records along the western South Atlantic between 27° and 39°S reveals that, although weaker in amplitude than the dramatic shifts of the last glacial cycle, the Brazil-Malvinas Confluence region showed substantial changes throughout the Holocene. The shift in the location of both, southern and northern source waters in the Atlantic implied a strengthening of the Southern Atlantic Meridional Overturning Circulation since the Mid-Holocene. This, together with the progressive southward displacement of the Brazil-Malvinas Confluence confirms the progressive weakening of the Atlantic Meridional Overturning Circulation towards the preindustrial times.