Assembling floating, very sparsely tethered, protein-lipid bilayers.

DOI

We have recently used Polref in to measure the assembly of tethered floating lipid bilayers. These are useful models of biological membranes in which a phospholipid bilayer is tethered to a solid surface by a molecular linker. The length of this linker can control the width of the water gap between the surface and the floating bilayer. Since they are easy to make and characterise , they promise an additional method to help us build accurate models of bacterial outer membranes. Here the water gap represents an important cellular compartment called the periplasm. Our previous POLREF experiments showed that we can assemble bilayers at very low tether densities which is important to minimise their effect on the membrane. Here we wish to show that we can insert and characterise proteins within the lipid bilayer which is another important step in creating useful models of living membranes

Identifier
DOI https://doi.org/10.5286/ISIS.E.84795212
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/84795212
Provenance
Creator Dr Martynas Gavutis; Professor Jeremy Lakey; Dr Nico Paracini; Dr Luke Clifton; Dr Christy Kinane
Publisher ISIS Neutron and Muon Source
Publication Year 2020
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering
Temporal Coverage Begin 2017-03-25T08:00:00Z
Temporal Coverage End 2017-03-27T07:00:00Z