The goal of this pragmatic, non-inferiority, randomized study was to evaluate efficacy and safety of a restrictive two-day course of intravenous antibiotic therapy versus a standard course of five days, following appendectomy for complex appendicitis. The primary endpoint was a composite endpoint of postoperative infectious complications (intraabdominal abscess or surgical site infection) and mortality within 90 days after appendectomy. Secondary objectives were, among other, all complications, reinterventions, readmission, length of stay, cost-effectiveness and adverse events on antibiotics (all within 90 days after appendectomy).

For the moment, only the study protocol is uploaded as a pdf. In the near future we will upload the raw study data here as well.