This data set reports neodymium (Nd) isotopic signatures at IODP Site 303-U1304 at the southern Gardar Drift in the North Atlantic to investigate changes in the deep water mass provenance from 374.3 to 468.5 ka covering Marine Isotope Stages (MIS) 12 and 11. The samples were taken along the shipboard splice and the age model of Xuan et al. (2016, doi:10.1016/j.quascirev.2016.04.010) was applied. The authigenic Nd isotopes were extracted from the sediment by bulk sediment leaching following the protocol of Blaser et al. (2016, doi:10.1016/j.chemgeo.2016.06.024). The isotope ratios were measured on a MC-ICP-MS (Neptune plus) coupled to a desolvator (Apex HF) at the Institute of Environmental Physics, Heidelberg University, Germany and were corrected to 146Nd/144Nd = 0.7219.