Lipidic cubic nanoparticles (LCNPs) have been extensively studied as therapeutic agents and delivery systems due to their biocompatibility, ease of drug encapsulation and targeting. Better understanding of the interplay between LCNPs and model lipid membranes is needed in order to exploit their use in clinical applications. We have shown that less condensed layers facilitate incorporation of the LCNPs material while highly organized layers keep the LCNPs intact and outside the monolayer, but specific information about the structure and composition of the system is missing. We propose to characterize the interactions of LCNPs at 2 surface pressures and with 2 different lipid monolayers (acting as simplified models of healthy and cancer cell membranes) using neutron reflectivity. Information about lipid exchange and particle attachment will pave the way for future drug release studies.