This dataset contains the semiquantitative data relative to the calcareous nannofossil assemblages from a subset of 26 samples from ODP Site 1053 core 8, Section 5. Samples span 74.54 to 75.20 m in composite depth, with a sample resolution that ranges from 1 to 10 cm. Data was collected From January to April 2023 and span a 1 M.y. long late Eocene Interval, Priabonian in age, that corresponds to the CNE19 nannofossil zone of the Priabonian (ca. 36 Ma; Agnini et al., 2014; Raffi et al., 2016). The samples from which the calcareous nannofossil assemblages were obtained were collected from ODP Site 1053, in the Blake Nose, NW Atlantic Ocean. This dataset has a regional resolution. Following previous results on bulk carbon and Oxygen stable isotopes, data was collected to further investigate the Blake Nose's regional paleoceanography during the Late Eocene.