A Total Scattering Investigation of the Intermolecular Interactions in Low Aqueous Solubility Amorphous Pharmaceuticals.

DOI

Low bioavailability is a major problem in drug formulation development; low aqueous solubility of an active pharmaceutical ingredient can stall development of a potentially useful drug through its limited bioavailability, and hence limited efficacy, after administration. The growing interest in the use of amorphisation in order to enhance solubility of active pharmaceutical ingredients has led to the investigation of methods to improve the stability of the amorphous state. The proposed experiment aims to use neutron total scattering information to investigate the intermolecular interactions formed in the amorphous state below and above the Tg and how these affect the molecular mobility. This will assist in understanding the storage conditions required to maintain shelf life stability, and understanding the metastable state prior to crystallisation.

Identifier
DOI https://doi.org/10.5286/ISIS.E.60668484
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/60668484
Provenance
Creator Dr Sam Callear
Publisher ISIS Neutron and Muon Source
Publication Year 2018
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Medicine; Natural Sciences
Temporal Coverage Begin 2015-05-01T10:42:17Z
Temporal Coverage End 2015-05-02T16:28:09Z