Sea surface temperature reconstruction (SST) over the last millennia in the Mediterranean area represent an important challenge to document the possible link of past climate variability on the rise and fall of ancient civilizations. In addition, the last report of the Intergovernmental Panel on Climate Change (IPCC 2018) underlines the requirement to assess climate feedbacks during past episodes of moderately warmer (1.5ºC-2°C) conditions.Within this framework, we present the reconstruction of the SST anomaly over the last five millennia based on the Mg/Ca ratios measured in the planktonic foraminifer /Globigerinoides ruber/ from the sediment core SW104-ND11 extracted in the western part of Sicily Channel (water depth 475 m, central Mediterranean Sea) during the oceanographic creuise NEXTDATA 2014 on board the Urania Vessel (CNR-Italy) wit the the SW104 corer. This new generated SST record is compared with previous published SST records reconstructed from Alboran Sea, Minorca Basin, Aegean Sea and from a north Hemisphere temperature reconstruction. This exercise provides the basis to discuss the regional impact of the most recent episode of apparently warmer conditions than present in the social-economical development of the Mediterranean region.