The goal of this experiment is to further our understanding of multistress interactions. We experimentally test for the influence of maternal age on the transcriptomic response to seleno-L-methionine (SeMet) exposure. Offspring were obtained from maternal populations (n=3) when the mothers were 8-days of age (young moms) and when the mothers were 32-days of age (old moms). The offspring were randomized to be reared in three SeMet treatment groups, 0-ug SeMet/L, 1-ug SeMet/L, or 4-ug SeMet/L.