This dataset is associated with the following publication: https://doi.org/10.5194/egusphere-2024-1735. It contains the water vapor mole fractions and bias correction magnitude (2010-2018) to the CO2 mole fractions measured at each airborne vertical profile site in the Amazon. The vertical profile data is freely available at: https://doi.pangaea.de/10.1594/PANGAEA.926834. The flags used to select the best quality data were: ALF: '...' and '..>' , TAB: '...' , TEF: '...' , SAN: '...' and '..>' , 'RBA: '...' . The water vapor was extracted from ECMWF-IFS using the STILT model (Lin et al., 2003). The water vapor mole fraction (wv_extr) is reported in % and the CO2 bias correction (bcorr) is in ppm. The bias correction has a systematic and a random component. The column bcorr_std provides the standard deviation of the bias for a given water vapor mole fraction bin of 1% (from 0 to 3%). Note that the standard deviation corresponds to the random component of the error, which is associated with the spread for each 1% bin. For the site RBA, there are 6 flights in which the water vapor correction was not applied because there was a drier installed. Those flights are not included in this dataset and the dates are (DDMMYYYY): 1. 16022018 / 2. 09032018 / 3. 06042018 / 4. 08052018 / 5. 15072018 / 6. 19092018