Investigation of the interactions of perfluoroalkyl substances with model worm and plant biomembranes

DOI

Perfluoroalkyl substances (PFASs) are fully fluorinated, stabile, and surface-active compounds. They contain both a hydrophobic fluorinated carbon chain and an ionizable hydrophilic functional group, and can interact with biological membranes through different pathways, such as adsorption, penetration and displacement. PFASs have been found to accumulate in organisms in the environment, but there is a lack of knowledge on the mechanisms behind the accumulation. This proposal aims to use neutron reflection to investigate the interactions of perfluorooctane sulfonate, perfluorononanoate and perfluorohexanoate with standard eukaryotic mimic biomembrane and compare with model plant membrane to elucidate the influence of different functional groups and chain lengths on the sorption/accumulation behavior at the two different types of membranes.

Identifier
DOI https://doi.org/10.5286/ISIS.E.84777722
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/84777722
Provenance
Creator Dr Arwel Hughes; Mr Hugo de Campos Pereira; Dr Sarah Josefsson; Dr Lutz Ahrens; Miss Shirin Nouhi; Dr Maja Hellsing
Publisher ISIS Neutron and Muon Source
Publication Year 2020
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Natural Sciences
Temporal Coverage Begin 2017-03-27T08:00:00Z
Temporal Coverage End 2017-03-31T08:00:00Z