The UK'37 sea surface temperature (SST) proxy, based on the distribution of long-chain akenones, was measured via mass spectrometry imaging (MSI) at 100-µm resolution in a 60-cm section of the well-dated core MD03-2621 from the Cariaco Basin (10.6782, -64.9715). This section spans an age of ~ 11.9 to 11.2 kyr b2k and thus includes the Younger Dryas-Holocene transition. The resulting record provides insights into interannual variability during this most recent glacial to interglacial transition. In order to translate UK'37 values into SST, a correction factor to account for differences between MSI-based data and conventional UK'37 data was applied. SST was calculated with the BAYSPLINE model.