-
Calcium mediated interaction between siRNA and phospholipid bilayers: the eff...
The main objective of the present study is to gain an understanding of the nature of the interaction of ¿phospholipid membranes¿ with small, interfering RNA (siRNA) in the... -
The Kinetics of Ethanol Adsorption into Cholesterol Rich Bilayers
In a recent experiment carried out on SURF we have shown that on addition of ethanol to a DPPC model membrane, the anaesthetic initially diffuses to the bilayer surface followed... -
The Interaction of Grp1 with Membranes Containing Signalling Phospholipids
This dataset has no description
-
Floating Bilayer Mimics of the Gram Negative Bacterial Outer Membrane
The gram-negative bacterial membrane is of extreme medical importance. The two main lipid components of the outer membrane are lipopolysaccharides (LPS's) and DOPE. We will... -
Adsorption of NHE1 intracellular domain on lipid bilayers
Recently the intracellular domain (ICD ) of the Na+/H+ exchanger isoform 1 (NHE1), is a transmembrane protein, has been identified as an intrinsically disordered protein.... -
Purothionins Perturb Bacterial Membrane Function via Ion Channel Formation
Purothionins are a family of cationic cystiene rich plant defence proteins which have been shown to have a wide spectrum of activity due their ability to permeate cellular... -
Structural evidence from SANS on self-assembly of antimicrobial lipopeptides ...
Previous studies have demonstrated that the de novo designed antimicrobial lipopeptides can self-assemble to beta-sheet nanofibers, but can transform to alpha-helical monomers... -
A model of the bacterial outer membrane containing both Outer Membrane Protei...
We have recently improved the stability and coverage of free standing bilayers (FSB) by the use of a supporting thiolipid layer on gold. The system has been investigated on... -
Conformational study of subtilin/lipid-II binary membrane complex formation.
Resistance to antibiotics is a major problem for the clinical management of infectious diseases, which are still a major cause of human mortality worldwide and resistance... -
NR Investigation of Structural Basis Underlying Synergistic Binding of Lipope...
In this part of the proposed work, we wish to explore how antibiotics and antimicrobial peptides interact with model lipid bilayers in the form of a supported lipid bilayer,... -
Understanding the interaction between antimicrobial peptide-loaded lipid part...
The number of antibiotic-resistant bacteria is increasing worldwide, and the demand for novel antimicrobials is constantly growing. Antimicrobial peptides (AMPs) could be an... -
Interaction of a pH-sensitive Polymer with a Model Lipid Membrane in the Form...
This SANS experiment was proposed by 4 PhD students from 3 different institutions in a Marie-Curie Training Network. They are all in the second year of their PhD and their... -
A comparative NR study of interaction of short designed antimicrobial peptide...
The global increase of bacterial resistance to antibiotics has led to increasing interest in research focusing on the development and characterization of new antimicrobial... -
Elucidating molecular mechanism of membrane disruption by designed α-hel...
We have previously shown that peptides such as G(IIKK)4I-NH2 (G4) can kill bacteria and inhibit cancer cell growth whilst remaining benign to mammalian host cells. We have also... -
Do hydroxyl radicals penetrate the organic monolayer at the air-water interface?
The Earth¿s climate is strongly influenced by clouds. The oxidative processing of pollutants in clouds affects droplet size and optical properties, important climatic effects.... -
Antimicrobial Mechanisms of Model Biocides via Their Interaction with Lipopol...
The global increase of bacterial resistance to antibiotics has led to increasing interest in research focusing on the development and characterization of new antimicrobial... -
pH-control of swelling and charge neutralization of thin hydrogel films
Hydrogels are widely used in biomaterials science, much due to excellent protein resistance, and physicochemical properties similar to biological tissue. Charge neutrality is... -
Temperature Dependence of the Oxidation of Monolayers Under Atmospheric Condi...
The Earth¿s climate is strongly influenced by clouds. The oxidative processing of pollutants in clouds affects cloud droplet size and optical properties, important climatic... -
Neutron reflectivity studies of the interaction of amphotericin with model ce...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin (AmB) has created a demand for novel anti-fungal agents that can circumvent the pathogens¿... -
NR study of binding of short antimicrobial alpha-helix peptides with model li...
In this work we explore how our rationally designed peptide amphiphiles bind onto lipid monolayers using neutron reflection combined with deuterium labelling to the lipids,...
