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Influence of Alkyl Chain Fluidity on the Membrane Binding Activity of Cationi...
Skin becomes a target of drug delivery because the transdermal routes are non-invasive, can be self-administrated, improves patient compliance and can provide a release for long... -
Membrane-stacking Properties of Mutant Myelin Proteins
Myelin is the multilamellar structure that ensheaths axons and accelerates nervous impulses in the nervous system. The fine structure of myelin remains to be further... -
Membrane-stacking Properties of Mutant Myelin Proteins
Myelin is the multilamellar structure that ensheaths axons and accelerates nervous impulses in the nervous system. The fine structure of myelin remains to be further... -
Interfacial conformation of antibody and antigen binding capacity
Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element... -
Polyoxometallate surfactant adsorption at solution surfaces
Polyoxometallates (POM) are well defined transition metal clusters with a range of interesting catalytic, magnetic and optical properties. To make efficient use of these... -
The role of disulphide bridges in the adsorption of globular proteins at the ...
Following our previous study of adsorption of globular lysozyme and BSA at the oil/water interface by neutron reflection, we continue to explore how unfolding of globular... -
Effect of Phosphatidylserine lipids on Tissue Factor structure and function i...
Tissue Factor (TF) is the membrane protein responsible for the initiation of the blood coagulation process [1]. In case of a vessel injury, the TF is exposed to the blood stream... -
Surfactants at the metal-oil interface
The lubrication of surfaces by oils is a key aspect of many academic and industrial problems with significant financial implications. We would like to study, for the first time... -
Co-adsorption of eggshell membrane polypeptide-surfactant mixtures at oil-in-...
An eggshell membrane polypeptide is highly surface active and effective at emulsion stabilization. We explore how to use SANS to study the interfacial layers surrounding the... -
Assessing the interactions of cyclic peptide-polymer conjugates with a lipid ...
Cyclic peptide-polymer nanotubes can readily self-assembly into long nanotubes, and are being extensively studied for drug delivery applications. As such, understanding how... -
NR characterization of aquaporin-containing silica-reinforced supported PC bi...
Despite the abundancy of sea water there are 663 million people that lack access to safe drinking water. This is due to excessive energy consumption and hence cost coupled to... -
Adsorption versus aggregation; Particles and surface of matching material
The balance between particle-surface and particle-particle interactions is entropically driven. We would like to investigate wherever a multiplayer layer adsorption on a... -
Interfacial Adsorption of Soluble Amino-Acid Based Surfactants in Mixtures wi...
Amino acid based surfactants have been known for many years, but so far few detailed studies have been carried out on their properties. We are using amino acids extracted from... -
Organization of mitochondrial membranes upon oxidative stress: Impact on apop...
Mitochondria are not only the powerhouse of the cell, but are also involved in cellular suicide via apoptosis (programmed cell death). The mitochondrial apoptotic pathway is a... -
Elucidating molecular mechanism of membrane disruption by designed α-hel...
We have previously shown that peptides such as G(IIKK)4I-NH2 (G4) can kill bacteria and inhibit cancer cell growth whilst remaining benign to mammalian host cells. We have also... -
Structure and conformation of thermo-responsive nanogels at air/water interfa...
Soft polymeric nanoparticles possess many interesting properties. Those based on N-isopropylacrylamide are surface active and respond to changes in temperature. This give rise... -
NR study of binding of short antimicrobial alpha-helix peptides with model li...
In this work we explore how our rationally designed peptide amphiphiles bind onto lipid monolayers using neutron reflection combined with deuterium labelling to the lipids,... -
Investigation on the air-water adsorption behaviour of N-acyl amino acid surf...
N-acyl amino acids are promising anionic amphiphilic molecules with an improved toxicological profile in comparison to the most common used sulfate-based surfactants. Previous... -
Self-assembly of detergent molecules below ambient temperature: SANS to deter...
Although surfactant detergency is well understood above 30 C, actions of surfactants below 30 C are not well established. In the era of energy saving and environment caring, we... -
Optimisation of a novel biosensor: the structure of the sensing layer
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