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An ex vivo model of Toxoplasma recrudescence reveals host-dependent pluripote...
Toxoplasma has been a useful parasite model for decades because it is relatively easy to genetically modify and culture, however, attempts to generate and study the... -
TgIF2K-B is an eIF2a kinase in Toxoplasma gondii that responds to oxidative s...
Here we report on gene expression changes in T. gondii in response to oxidative stress induced by sodium arsonite in wild-type and TgIF2K-B knockout intracellular parasites.... -
Transcriptomics of Toxoplasma gondii sporulating oocysts
Toxoplasma gondii is an apicomplexan parasite that approximately infects one third of the human population worldwide. When sporulated oocysts that are shed in the faeces of... -
A MORC-driven transcriptional switch controls Toxoplasma developmental trajec...
Toxoplasma gondii has a complex life cycle that is typified by asexual development that takes place in vertebrates, and sexual reproduction, which occurs exclusively in felids... -
Comparative ribosome profiling uncovers a dominant role for translational con...
The lytic cycle of the protozoan parasite Toxoplasma gondii, which involves a brief sojourn in the extracellular space, is characterized by defined transcriptional profiles. For... -
Cyclical transcription factor AP2XII-9 is a key activator for asexual divisio...
Toxoplasma gondii is an intracellular parasitic protozoan that poses a significant risk to pregnant women and immunocompromised individuals. T. gondii tachyzoites duplicate... -
A potent HDAC inhibitor blocks Toxoplasma gondii tachyzoite growth and profou...
Toxoplasmosis is a major health issue worldwide especially for immune-deficient individuals and the offspring of newly infected mothers. It is caused by a unicellular... -
Genome sequencing project of T. gondii, strain TgCatJpOk4
To understand the genomic composition of T. gondii in Japan, we are sequencing the genome of Japanese isolates in our genomic sequencing project of T. gondii. As part of the... -
Transcriptome analysis of Toxoplasma gondii in altered iron conditions
An RNA-sequencing study to identify genes involved in iron detoxification of the important human pathogen Toxoplasma gondii. In this project the transcriptomes of parasites... -
A MORC-driven transcriptional switch controls Toxoplasma developmental trajec...
Purpose: T. gondii has a complex life cycle typified by an asexual development taking place in vertebrate and a sexual reproduction occurring exclusively in felids and thereby... -
Brain transcriptome of mice infected with T. gondii parasites
Mice were infected with up to 250,000 tachyzoites of T. gondii VEG strain parasites genetically engineered to be deficient in either the ROCY1 gene (TGVEG_311100) or the BFD1... -
RNA-sequencing of parasites overexpressing conditionally stabilized BFD1 to i...
WT (ME49?KU80), ?BFD1, or ?BFD1/DD-BFD1-Ty parasites were treated with the stabilizing ligand Shield-1 (all three) or vehicle alone (WT and ?BFD1/DD-BFD1-Ty) to identify genes... -
A unique Toxoplasma gondii haplotype accompanied the global expansion of cats.
Toxoplasma gondii is a cyst-forming apicomplexan parasite of virtually all warm-blooded species, with all true cats (Felidae) as definitive hosts. It is the etiologic agent of... -
Dual RNA-seq analyses of porcine alveolar macrophage and Toxoplasma during in...
Purpose:This study was aimed to profile the transcriptome changes during Toxoplasma infection with porcine alveolar macrophages. for this purpose, Porcine alveolar macrophages... -
The raw sequence reads of DiCre Delta SBPase Delta TAL strain
TgSBPase and TgTAL double-deletion strain -
High-throughput identification of Toxoplasma gondii effector proteins that ta...
Intracellular pathogens and other endosymbionts reprogram host cell transcription to suppress immune responses and recalibrate biosynthetic pathways. This reprogramming is... -
Toxoplasma gondii RNASeq
Recent advances in high throughput sequencing methodologies allow the opportunity to probe in depth the transcriptomes of organisms including N. caninum and Toxoplasma gondii.... -
Depletion of mRNA cap-binding protein eIF4E1 drives bradyzoite formation in T...
Ingestion of Toxoplasma gondii results in life-long infection due to its ability to convert from the rapidly disseminating tachyzoite stage to the chronic, encysted bradyzoite... -
Whole genome sequencing of Toxoplasma gondii parasite resistant to artemisinin
Artemisininsare effective against a variety of parasites and provide the first line of treatment for malaria. Laboratory studies have identified several mechanisms for... -
Sequence of T. gondii iDTPC cell line
This is the sequence result of the iDTPC, iDTPC-TR, and clean knockout of TPC cell lines we created.