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Investigating liposome sensitivity towards phospholipases for applications in...
Liposomes are lipid-based, water-filled vesicles with wide-ranging applications in diagnostics and drug delivery. Phospholipases (PLs) are enzymes that cleave specific bonds in... -
Follwing in situ oxidation of lipids rafts by SANS
The lateral organisation of lipids in the cell membrane is crucial for many biological processes, however techniques to follow this organization are scarce. We have developed a... -
Effect of End Group on RAFT-Polymers for Lipid Nanodisc Stabilisation
Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Previously we studied discs formed using... -
Kinetics of the formation of eumelanin and its intermediates
The proposed research project is targeted to the investigation of the characteristics of eumelanin, a heterogeneous material insoluble in water and in any organic solvent, as... -
SANS Studies of Nanostructures of Microfluidically Fabricated lipid Nanoparti...
We have developed a new approach for forming lipid nanoparticles (LNP) with and without interfering RNA and DNA from a microfluidic setup. The LNPs are formed by an ionisable... -
Hydrophobicity ¿ The Key to Polymer-Drug Conjugate Conformation
The use of polymer-drug conjugates for the delivery of drugs to specific sites of disease within the body has shown much clinical promise. It has become clear that the... -
A melanin-inspired pro-oxidant system for dopa(mine) polymerization: implicat...
Melanins are the major determinants of pigmentation of skin, hair and eyes in humans. These pigments originate from the tyrosinase-catalyzed oxidation of tyrosine, leading to... -
RESUBMISSION : DNA hybridisation-mediated vesicle fusion - kinetics and fate ...
Controlled vesicle fusion has major advantages in diagnostic and drug delivery applications. We have designed a DNA hybridisation-based assay for directed fusion of vesicles... -
Solution structures of the immunologically important proteins IgA and C3b
We are unravelling the solution structures of the Fab and Fc fragments in the IgA antibody family important in mucosal immunology. Having completed the structures for IgA... -
Using contrast matching to understand the networks in multicomponent systems
We have been focusing on two component gel networks. Here, both components can individually form gels. In a mixed system, the LMWG can either co-assemble or self-sort. In a... -
Assembly of supramolecular nanotubes into tubisome structures from self-assem...
Cyclic peptide-polymer conjugates can readily self-assembly into long nanotubes, and are being extensively studied for biomedical applications. Recently, we have conjugated a... -
A SANS Study of Hierarchical Order in DNA Complexes with Trojan Peptides
We will use SANS to investigate the nanoscopic structure i.e., sizes in the range 2-200 nm of complexes formed by cell-penetrating peptides and nucleic acid species. The...
