A_targeted_amplicon_sequencing_panel_to_simultaneously_identify_mosquito_species_and_Plasmodium_presence_across_the_entire_Anopheles_genus

Anopheles is a diverse genus of mosquitoes comprising over 500 described species, including all known human malaria vectors. While a limited number of key vector species have been studied in detail, the goal of malaria elimination calls for surveillance of all potential vector species. Here, we develop a multilocus amplicon sequencing approach that targets 62 highly variable loci in the Anopheles genome and two conserved loci in the Plasmodium mitochondrion, simultaneously revealing both the mosquito species and whether that mosquito carries malaria parasites. The panel can be applied to over 1000 individual mosquitoes in a single MiSeq run, and we demonstrate its power to assign species identity using sequencing data for 40 species from Africa, Southeast Asia, and South America. We also show that the approach can be used to resolve geographic population structure in An. gambiae and An. coluzzii populations, as the population structure determined based on these 62 loci from over 1000 mosquitoes closely mirrors that revealed through whole genome sequencing. The end-to-end approach is quick, inexpensive, robust, and accurate which makes it a promising technique for very large scale mosquito genetic surveillance and vector control. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/

Identifier
Source https://data.blue-cloud.org/search-details?step=~012F705EE0D5218718A8EC815994D05B24822D8631D
Metadata Access https://data.blue-cloud.org/api/collections/F705EE0D5218718A8EC815994D05B24822D8631D
Provenance
Instrument Illumina MiSeq; ILLUMINA
Publisher Blue-Cloud Data Discovery & Access service; ELIXIR-ENA
Publication Year 2024
OpenAccess true
Contact blue-cloud-support(at)maris.nl
Representation
Discipline Marine Science
Temporal Point 2021-02-09T00:00:00Z