These data provide single cell transcriptomic sequences for fibroblastic stromal cells (CD45-CD31-) and immune cells (CD45+CD31+) isolated from murine skin-draining lymph nodes. We have compared Wild type C57BL/6J mice with a genetically modified PdgframGFP-CreERT2 x Pdpnflox/flox to induce deletion of the gene encoding Podoplanin conditionally from fibroblasts.These data support the publication - https://doi.org/10.1101/2022.12.01.518753Files included:Raw data h5 files, 10X Genomics transcriptional sequencingControl_CD45-CD31-,PDPNdel_CD45-CD31-,Control_CD45+CD31+PDPNdel_CD45+CD31+