Structural studies on drugs and lipids in amphiphilic solutions

DOI

How drugs cross the formidable blood brain barrier in order to function is not well understood, specifically with respect to the interplay between hydrophobic and hydrophilic interactions in solution. BBB-crossing drugs must be hydrophilic enough to be delivered to the brain through the blood stream, yet hydrophobic enough to cross into the central nervous systems. Here we propose to investigate the atomic structure of a drug which can cross the BBB with lipids in amphiphilic solutions which mimic the environment presented by the the central nervous system. This will provide atomic scale insights into the mechanisms by which drugs molecules can pass into the brain in order to function.

Identifier
DOI https://doi.org/10.5286/ISIS.E.67772869
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/67772869
Provenance
Creator Dr Sylvia McLain; Dr Sam Callear; Dr Ric Gillams; Mr Christopher Sowden; Mr Andrew Johnston; Dr Natasha Rhys; Dr Richard Gillams
Publisher ISIS Neutron and Muon Source
Publication Year 2018
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering
Temporal Coverage Begin 2015-11-16T09:00:00Z
Temporal Coverage End 2015-11-21T09:00:00Z