The dataset presented here captures 114 uranium isotope ratio (234U/238U), expressed as δ²³⁴U, in a coral from northern Cuba, with data spanning the past 230 years. The primary objective was to analyze the variability in δ²³⁴U to evaluate freshwater fluxes and oceanographic changes in the northern Caribbean, particularly during the Little Ice Age (LIA). Annual variations of δ²³⁴U were measured using multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS), achieving an external precision of ±0.55‰.